Mast Cell-Nerve Interactions.

INFLUENCE OF NERVE TISSUE-DERIVED NEUROTRANSMITTERS ON MAST CELL MIGRATION

In vitro culture systems using bone marrow cells from BALB/C mice were set up in medium supplemented with spleen-derived medium. Bone marrow cells grown in spleen-derived medium gave rise to cultures containing >97% mast cells. The cells were used in polarisation chemotaxis assays with the intention of determining the effect of nerve tissue-derived neurotransmitters on mast cell migration. ...

MAST CELLS IN THE TYMPANIC PART OF THE FACIAL NERVE IN CHRONIC OTITIS MEDIA WITHOUT ASSOCIATED FACIAL PARALYSIS

The occurrence of mast cells is studied in the normal facial nerve and in the facial nerve post mortem exam of patients with chronic suppurative otitis media without associated facial paralysis. A small number of mast cells were found in the normal facial nerve. These cells were usually located in close proximity to the endoneural and epineural blood vessels. The number of mast cells was i...

The mast cell-nerve functional unit: a key component of physiologic and pathophysiologic responses.

A key characteristic of mast cells appears to be an ability to span the division between nervous and immune system. Indeed, much of our understanding of the bi-directional relationship between the nervous and immune systems has come from the study of mast cell-nerve interaction. Although differences in species have been reported, morphologic as well as functional associations between mast cell ...

Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions.

IgE-dependent activation of mast cell activation is often associated with symptoms attributed to activation of sensory nerves. Depending on the tissues involved such symptoms include itching, sneezing, irritation, vasodilation, and reflex secretions. In the present study, we hypothesize that sensory neuroactive mediators released from mast cells may include agonists of recently discovered orpha...

A preclinical model of malignant peripheral nerve sheath tumor-like is characterized by infiltrating mast cells

Human melanomas exhibit considerable genetic, pathological, and microenvironmental heterogeneity. Genetically engineered mice have successfully been used to model the genomic aberrations contributing to melanoma pathogenesis, but their ability to recapitulate the phenotypic variability of human disease and the complex interactions with the immune system have not been addressed. Here we report t...

Omri Bauer and Ehud Razin Mast Cell - Nerve Interactions